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MALATE DEHYDROGENASE
| Flammability | 1 | |
| Toxicity | 0 | |
| Body Contact | 0 | |
| Reactivity | 0 | |
| Chronic | 2 | |
| SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 | ||
Enzyme used for analytical purposes e.g. the determiantion of oxaloacetate, malate or
tartrate Specific for the L- configuration, D- malate, D- tatrate do not react.
"enzyme (EC 1.1.1.37)", "malic dehydrogenase", MDH, L-MDH, L-MDH
Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre- existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern. Considered an unlikely route of entry in commercial/industrial environments.
Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).
The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. Respiratory sensitization may result in allergic/asthma like responses; from coughing and minor breathing difficulties to bronchitis with wheezing, gasping.
There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.
Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust. Dusts produced by enzymes can attack the respiratory system. Allergic asthma produced after exposure includes spasm, cough and wheezing. Other symptoms include chronic cough, phlegm, fever, muscle pains, fatigue, airway obstruction, and scarring at the top or base of the lungs. There may also be abdominal pain, headache, stomach-ache and a general feeling of unwellness. Prolonged contact can result in skin soreness, redness, inflammation and possible ulceration. There may also be loss of lung function due to scarring.
