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URACIL ARABINOSIDE
| Flammability | 1 | |
| Toxicity | 0 | |
| Body Contact | 1 | |
| Reactivity | 0 | |
| Chronic | 2 | |
| SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 | ||
A pyrimidine nucleoside.
C9-H12-N2-O6, "uracil, 1beta-D-arabinofuranosyl-", "uracil, 1beta-D-arabinofuranosyl-",
"2, 4(1H, 3H)-pyrimidinedione, 1beta-D-arabinofuranosyl-", "2, 4(1H, 3H)-pyrimidinedione,
1beta-D-arabinofuranosyl-", arabinosyluracil, arabinofuranosyluracil, 1beta-D-
arabinofuranosyluracil, 1beta-D-arabinofuranosyluracil, Arauridine, Ara-U, Spongouridin,
Spongouridine
Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre- existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern. Considered an unlikely route of entry in commercial/industrial environments.
Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn). The dust may produce eye discomfort causing smarting, pain and redness.
The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.
Principal routes of exposure are usually by skin contact/absorption and inhalation of generated dust. Exposure to small quantities may induce hypersensitivity reactions characterized by acute bronchospasm, hives (urticaria), deep dermal wheals (angioneurotic edema), running nose (rhinitis) and blurred vision . Anaphylactic shock and skin rash (non-thrombocytopenic purpura) may occur. An individual may be predisposed to such anti-body mediated reaction if other chemical agents have caused prior sensitization (cross-sensitivity). A study in mice given 90 mg/kg of uracil arabinoside revealed evidence of foetal harm.
