西亞試劑：Norfriedelins A–C with Acetylcholinesterase Inhibitory Acti

Norfriedelins A–C with Acetylcholinesterase Inhibitory Activity from Acerola Tree (Malpighia emarginata)

Jie-Qing Liu †, Xing-Rong Peng †‡, Xu-Yang Li †‡, Ting-Zhao Li §, Wei-Ming Zhang †‡, Lei Shi †, Jiang Han §, and Ming-Hua Qiu *†‡

Three novel norfriedelanes, A–C (1–3), were isolated from the branches and roots of Malpighia emarginata. Their structures and absolute configurations were determined by 1D and 2D NMR techniques and X-ray crystallographic analysis. Norfriedelin A (possessing an α-oxo-β-lactone group) and norfriedelin B (with a keto-lactone group) showed acetylcholinesterase inhibitory effects with the IC50 values of 10.3 and 28.7 μM, respectively.

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