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Modulation of Human Glutathione S-Transferases by Polyphenon E Intervention
H.-H. Sherry Chow1, Iman A. Hakim1, Donna R. Vining1, James A. Crowell3, Margaret E. Tome2, James Ranger-Moore1, Catherine A. Cordova1, Dalia M. Mikhael1, Margaret M. Briehl2 and David S. Alberts1
1 Arizona Cancer Center and 2 Department of Pathology, The University of Arizona, Tucson, Arizona and 3 Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland
Requests for reprints: H.-H. Sherry Chow, Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724. Phone: 520-626-3358; Fax: 520-626-5348. E-mail: Purpose: Green tea consumption has been associated with decreased risk of certain types of cancers in humans. Induction of detoxification enzymes has been suggested as one of the biochemical mechanisms responsible for the cancer-preventive effect of green tea. We conducted this clinical study to determine the effect of repeated green tea polyphenol administration on a major group of detoxification enzymes, glutathione S-transferases (GST).
Methods: A total of 42 healthy volunteers underwent a 4-week washout period by refraining from tea or tea-related products. At the end of the washout period, a fasting blood sample was collected, and plasma and lymphocytes were isolated for assessment of GST activity and level. Following the baseline evaluation, study participants underwent 4 weeks of green tea polyphenol intervention in the form of a standardized Polyphenon E preparation at a dose that contains 800 mg epigallocatechin gallate (EGCG) once a day. Polyphenon E was taken on an empty stomach to optimize the oral bioavailability of EGCG. Upon completion of the intervention, samples were collected for postintervention GST assessment.
