Enzymatic total synthesis of enterocin polyketides
Qian Cheng1,2, Longkuan Xiang2, Miho Izumikawa2, Dario Meluzzi3 & Bradley S Moore1,2,3
Polyketides are clinically important natural products that often require elaborate organic syntheses owing to their complex chemical structures. Here we report the multienzyme total synthesis of the Streptomyces maritimus enterocin and wailupemycin bacteriostatic agents in a single reaction vessel from simple benzoate and malonate substrates. To our knowledge, our results represent the first in vitro assembly of a complete type II polyketide synthase enzymatic pathway to natural products.
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Scripps Institution of Oceanograph, University of Arizona, 1703 E. Mabel Street, Tucson, Arizona 85721, USA.
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College of Pharmacy, University of Arizona, 1703 E. Mabel Street, Tucson, Arizona 85721, USA.
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Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Correspondence to: Bradley S Moore1,2,3 Email
