西亞試劑：Atomic Structure of Human Adenovirus by Cryo-EM Reveals Int

Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks

Hongrong Liu,1,2,3 Lei Jin,1,2 Sok Boon S. Koh,4 Ivo Atanasov,2 Stan Schein,2,5,6 Lily Wu,2,4 Z. Hong Zhou1,2,*

Construction of a complex virus may involve a hierarchy of assembly elements. Here, we report the structure of the whole human adenovirus virion at 3.6 angstroms resolution by cryo–electron microscopy (cryo-EM), revealing in situ atomic models of three minor capsid proteins (IIIa, VIII, and IX), extensions of the (penton base and hexon) major capsid proteins, and interactions within three protein-protein networks. One network is mediated by protein IIIa at the vertices, within group-of-six (GOS) tiles—a penton base and its five surrounding hexons. Another is mediated by ropes (protein IX) that lash hexons together to form group-of-nine (GON) tiles and bind GONs to GONs. The third, mediated by IIIa and VIII, binds each GOS to five surrounding GONs. Optimization of adenovirus for cancer and gene therapy could target these networks.

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